Related Experiment Video
Updated: Apr 8, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
Published on: December 5, 2025
Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits
Xingxing Wu1, Yulin Chen1, Shuangying Gui1,2
1a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
Abstract:
Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.
More Related Videos
Related Concept Videos
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Drug Permeability Enhancement
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Ophthalmic Drug Delivery Systems

