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Related Concept Videos

Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.9K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Related Experiment Video

Updated: Apr 8, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
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Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

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Procalcitonin.

Julie Davies

    Journal of Clinical Pathology
    |July 1, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Procalcitonin (PCT) aids in diagnosing bacterial infections and guiding antibiotic therapy. While PCT shows promise in combating antibiotic resistance, its cost-effectiveness and impact on resistance development require further investigation.

    Keywords:
    AIRWAYS DISEASEANTIBIOTICSBIOCHEMISTRY

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    Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
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    Area of Science:

    • Biochemistry
    • Infectious Diseases
    • Endocrinology

    Background:

    • Procalcitonin (PCT) is a precursor to calcitonin, with synthesis influenced by bacterial and viral infections.
    • Antibiotic resistance necessitates novel diagnostic and therapeutic strategies.
    • PCT's role in infection management and resistance mitigation is under increasing scrutiny.

    Purpose of the Study:

    • To review the diagnostic and therapeutic applications of PCT in various clinical settings.
    • To evaluate the potential of PCT in managing antibiotic resistance.
    • To discuss the clinical utility and cost-effectiveness of PCT.

    Main Methods:

    • Literature review of studies on Procalcitonin (PCT) in infection diagnosis and management.
    • Analysis of PCT's role in primary care, emergency departments, and intensive care units.
    • Assessment of evidence linking PCT use to antibiotic resistance reduction.

    Main Results:

    • PCT levels correlate with bacterial infection severity and are suppressed by viral infections.
    • PCT can aid in diagnosing infections and tailoring antibiotic treatment duration.
    • Evidence for PCT's direct impact on slowing antibiotic resistance is largely circumstantial.

    Conclusions:

    • Procalcitonin is a valuable biomarker for infection, particularly bacterial.
    • PCT's utility in reducing antibiotic resistance requires more robust evidence.
    • The cost-effectiveness of PCT depends on clinical context and requires further validation.