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Second Primary Malignancy in Anal Carcinoma--A US Population-based Study.

Binay Kumar Shah1, Nibash Budhathoki2

  • 1Cancer Center and Blood Institute, St. Joseph Regional Medical Center, Lewiston, ID, U.S.A. binay.shah@gmail.com.

Anticancer Research
|July 1, 2015
PubMed
Summary
This summary is machine-generated.

Patients with anal cancer face a significantly higher risk of developing second primary malignancies. This increased risk affects various cancer types and is influenced by age, radiotherapy, and time since diagnosis.

Keywords:
Anal cancerSEERlatencysecond primary malignancy

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Area of Science:

  • Oncology
  • Cancer Epidemiology

Background:

  • Limited data exists on the incidence of second primary malignancies in anal cancer patients.
  • Anal carcinoma patients represent a unique cohort for studying secondary cancer risks.

Purpose of the Study:

  • To evaluate the risk of developing second primary malignancies in patients diagnosed with anal carcinoma.
  • To identify specific cancer types with increased incidence following an anal cancer diagnosis.

Main Methods:

  • Utilized the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) 13 database.
  • Included adult patients diagnosed with anal cancer.
  • Calculated the risk of second primary malignancies using the standardized incidence ratio (SIR) method.

Main Results:

  • A total of 7,661 anal cancer patients were analyzed, with 675 (9.07%) developing 747 second primary malignancies.
  • An overall increased risk of second primary malignancies was observed (SIR=1.41, p<0.001).
  • Elevated risks were noted for oral cavity/pharynx, rectum/anal canal, larynx, lung/bronchus, ovary, vagina, vulva, Kaposi's sarcoma, and hematological malignancies.

Conclusions:

  • Adult patients with anal cancer have a significantly elevated risk of developing second primary malignancies compared to the general population.
  • The risk is influenced by patient age, prior radiotherapy exposure, and latency period.
  • Further research is warranted to understand the underlying mechanisms and optimize surveillance strategies.