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Effect of Celecoxib on Survival of Mobile Tongue Cancer
Doh Young Lee1, Jae Hyun Lim2, Yoon Joong Kim2
1Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Anam Hospital, Seoul, Republic of Korea.
Aim:
The goal of the present study was to evaluate the effects of celecoxib on treatment outcomes of squamous cell carcinoma of the mobile tongue.
Patients And Methods:
Among 158 patients who were diagnosed with mobile tongue cancer, 19 received celecoxib during the preoperative, postoperative, or post-recurrence phase. Differences in disease-specific survival (DSS) and recurrence-free survival (RFS) between patients who received celecoxib (study group) and those who did not (control group) were analyzed.
Results:
For the entire cohort, DSS and RFS were not significantly different according to duration of celecoxib treatment (p=0.293 and 0.703, respectively). Among patients who received chemotherapy, DSS was significantly higher in the study group than in the control group (p=0.048), but RFS was not different between the two groups (p=0.117).
Conclusion:
When combined with chemotherapy, celecoxib may have a beneficial effect on the survival of patients with mobile tongue cancer.
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