Related Experiment Video
Updated: Apr 8, 2026
06:07
Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
Published on: December 17, 2021
6.2K
Extra pontine osmotic demyelination syndrome
Pervaiz M Zunga1, Omar Farooq1, Mohd I Dar1
1Department of Internal Medicine Smhs Hospital Gmc Srinagar Kashmir, INDIA.
Annals of Neurosciences
|July 1, 2015
Summary
Osmotic demyelination syndrome (ODS) can occur from rapid hyponatremia correction. This case highlights ODS management in a patient with persistent encephalopathy despite electrolyte correction.
Area of Science:
- Neurology
- Internal Medicine
- Nephrology
Background:
- Osmotic demyelination syndrome (ODS) is a neurological complication historically linked to rapid correction of hyponatremia.
- Recent research indicates ODS can arise from various conditions independent of serum sodium levels, involving brain cell dehydration and axonal injury.
- Preventative strategies include slow serum sodium correction and corticosteroid administration.
Observation:
- A rare case of ODS is presented in a 65-year-old female with altered sensorium, vomiting, and diarrhea.
- The patient initially received intravenous fluids, leading to encephalopathy upon referral.
- Initial evaluation revealed hyponatremia and hypokalemia; other biochemical and septic profiles were normal.
Findings:
- Despite guideline-based management of electrolyte disturbances, the patient's encephalopathy persisted.
- Supportive treatment was administered throughout the patient's hospitalization.
- The patient eventually recovered full sensorium and neurological functions after a two-week hospital stay.
Implications:
- This case underscores the complexity of ODS, even when not directly tied to rapid hyponatremia correction.
- It emphasizes the importance of continued supportive care in managing persistent neurological deficits associated with ODS.
- Further research into non-hyponatremia-related ODS triggers and management is warranted.
