Flunarizine does not delay the development of generalized seizures by amygdala kindling

Adult rats underwent amygdala kindling after the administration of vehicle, flunarizine 20 mg/kg/day, or flunarizine 40 mg/kg/day. Stimuli were delivered thrice daily at current intensities twice after-discharge threshold (ADT). Flunarizine did not alter initial or post-kindling ADT and did not affect the latency (number of stimuli) to the first stage 5 seizure. Apart from a tendency to increase the latency between the first and the 4th stage 5 seizures, flunarizine had little if any effect on amygdala kindling in this protocol.