Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

34.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.4K
Epigenetic Regulation01:37

Epigenetic Regulation

4.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

26.3K
26.3K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.9K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

38.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.8K
Inheritance01:25

Inheritance

1.9K
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Murine Model of Radiation Dermatitis with Experimental Wound and Effects of Genistein.

International journal of molecular sciences·2026
Same author

Metastatic tropism of molecularly defined clear-cell renal cell carcinoma clusters.

The Journal of clinical investigation·2026
Same author

Comprehensive Genomic and Transcriptomic Characterization of Matched Primary and Recurrent Tumors in High-risk Localized Renal Cell Carcinoma.

European urology·2026
Same author

γ-Radiation induces region-specific subcellular alterations of amyotrophic lateral sclerosis and frontotemporal dementia markers in swine brain.

Scientific reports·2026
Same author

Functional analysis of AIP variants in a cohort of neuroendocrine neoplasms.

Endocrine-related cancer·2025
Same author

Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model.

NPJ Parkinson's disease·2025

Related Experiment Video

Updated: Apr 8, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.0K

Episensitization: Defying Time's Arrow.

Bryan T Oronsky1, Arnold L Oronsky2, Michelle Lybeck1

  • 1EpicentRx, Inc. , Mountain View, CA , USA.

Frontiers in Oncology
|July 1, 2015
PubMed
Summary
This summary is machine-generated.

Episensitization resets the tumor

Keywords:
RRx-001epigeneticsepigenomicepisensitizationoncologyresensitization

More Related Videos

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

11.0K
Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

5.0K

Related Experiment Videos

Last Updated: Apr 8, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.0K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

11.0K
Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

5.0K

Area of Science:

  • Cancer biology and epigenetics
  • Translational oncology

Background:

  • Cancer develops due to genetic and epigenetic alterations leading to uncontrolled cell growth.
  • Epigenetic modifications, such as DNA methylation and histone acetylation, are crucial in regulating genes involved in cell growth and apoptosis.
  • Acquired therapeutic resistance is a major challenge in cancer treatment.

Purpose of the Study:

  • To define and evaluate the therapeutic strategy of episensitization.
  • Episensitization aims to resensitize cancer cells to therapy by resetting the tumor's epigenetic infrastructure.
  • This approach challenges the conventional view that previously failed therapies are clinically useless.

Main Methods:

  • Review of basic principles of episensitization.
  • Highlighting evidence for epigenetic mechanisms reversing drug resistance, including histone hypoacetylation and DNA hypermethylation.
  • Discussion of the role of microenvironment in epigenetic control of gene expression.

Main Results:

  • Epigenetic changes are reversible and can restore treatment susceptibility.
  • Episensitization offers a novel strategy to prevent treatment discontinuation upon resistance development.
  • Evidence suggests histone hypoacetylation and DNA hypermethylation can reverse clinical drug resistance.

Conclusions:

  • Episensitization is a practical strategy to overcome acquired therapeutic resistance in cancer.
  • This approach can significantly extend patient survival by preventing premature cessation of treatment.
  • The review highlights epigenetic agents like decitabine, vorinostat, entinostat, 5-azacitidine, oncolytic viruses, and RRx-001.