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Fatal infectious mononucleosis with staphylococcal pyoderma in a girl with hereditary immunological dysregulations
T Inaba1, R Hanada, A Yaginuma
1Division of Haematology/Oncology, Saitama Children's Medical Center, Japan.
European Journal of Pediatrics
|December 1, 1989
Abstract:
We describe a 14-year-old girl with fatal infectious mononucleosis with high fever, pancytopenia, and multiple skin ulcers due to Staphylococcus aureus. Immunological studies revealed low serum IgM, low natural killer (NK) activity, and high CD4/CD8 ratio. Her father had also low NK activity and high CD4/CD8 ratio. It is suggested that she had a dominantly inherited immunodeficiency predisposing to severe Epstein-Barr virus infection.