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Prevalence of Helicobacter pylori infection in pediatric celiac disease

J Jozefczuk1, B Bancerz, M Walkowiak

  • 1Pediatric Department with Children's Cardiologic Subunit, Specialist Hospital of Holy Spirit in Sandomierz, Sandomierz, Poland. jarwalk@ump.edu.pl.

European Review for Medical and Pharmacological Sciences
|July 1, 2015
PubMed

Insights

Helicobacter pylori (Hp) infection prevalence was similar in pediatric celiac disease (CD) patients and healthy children. This study found no significant difference in Hp infection rates between these groups, suggesting Hp may not play a role in CD development.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Immunology

Background:

  • Previous studies suggested a potential inverse relationship between Helicobacter pylori (Hp) infection and celiac disease (CD) risk.
  • The prevalence of Hp infection in pediatric CD patients has not been well-established compared to the general population.

Purpose of the Study:

  • To investigate the frequency of Hp infection in children diagnosed with CD.
  • To compare Hp infection rates in pediatric CD patients with age-matched healthy individuals.

Main Methods:

  • A cohort of 74 pediatric CD patients (ages 3-12) underwent Hp diagnosis using the stable isotope breath test.
  • A control group of 296 age-matched healthy subjects was included for comparison.
  • Hp infection was assessed as part of the differential diagnosis for CD.

Main Results:

  • Hp infection was detected in 5.4% of pediatric CD patients and 6.8% of healthy controls.
  • No statistically significant difference in Hp infection prevalence was observed between CD patients and healthy subjects across all age groups (p=0.5713).
  • Subgroup analysis for ages 3-6 years (2.5% vs. 3.7%, p=0.8551) and 7-12 years (8.8% vs. 11.0%, p=0.8742) also showed no significant difference.

Conclusions:

  • The prevalence of Hp infection in pediatric CD patients is comparable to that in the general healthy population.
  • Further research is warranted to explore any potential role of Hp in the pathogenesis of celiac disease.
  • Current findings do not support a protective role of Hp infection against CD in children.
Abstract

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