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Diabetes associated with pancreatic diseases
1Division of Diabetology and Gastrointestinal Endocrinology, St. Josef-Hospital Bochum, Ruhr-University Bochum, Bochum, Germany.
Current Opinion in Gastroenterology
|July 1, 2015
Summary
Patients with pancreatic disorders often develop secondary diabetes, requiring tailored treatments. Early screening for diabetes in pancreatic disease is crucial due to links with cancer and pancreatitis risk.
Area of Science:
- Endocrinology
- Gastroenterology
- Oncology
Background:
- Pancreatic disorders are frequently associated with secondary diabetes, impacting glucose homeostasis.
- Epidemiological studies highlight bidirectional links between diabetes and pancreatic diseases like cancer and pancreatitis.
Purpose of the Study:
- To review the literature on diabetes in patients with pancreatic disorders.
- To summarize the relationship between pancreatic damage and glucose metabolism.
- To discuss the impact of diabetes on pancreatic cancer and pancreatitis risk and treatment challenges.
Main Methods:
- Literature review of studies on diabetes in acute/chronic pancreatitis and pancreatic carcinoma.
- Analysis of the relationship between pancreatic damage, insulin, and glucose homeostasis.
- Discussion of treatment caveats for pancreaticogenic diabetes.
Main Results:
- Pancreatic diseases are linked to impaired glucose homeostasis and secondary diabetes.
- Diabetes mellitus increases the risk of pancreatic cancer and pancreatitis.
- Pancreaticogenic diabetes may present an increased risk of hypoglycemia.
Conclusions:
- Screening for diabetes in pancreatic disease patients using oral glucose tolerance tests is recommended.
- Newly diagnosed diabetes can indicate pancreatic cancer; diabetes increases pancreatic cancer/pancreatitis risk.
- Further research is needed for optimal glucose-lowering treatments in pancreaticogenic diabetes.
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