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DOI is a mixed agonist-antagonist at postjunctional 5-HT2 receptors in the pithed rat
H Dabiré1, K Chaouche-Teyara, C Cherqui
1INSERM U 228, Faculté de Médecine Broussais Hôtel-Dieu, Paris, France.
European Journal of Pharmacology
|October 24, 1989
Abstract:
The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic properties in the pithed rat.