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Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification

J P Liu1, X W Wang1, L P Qie1

  • 1Pediatric Department of Hematology, Inner Mongolia People's Hospital, Huhhot, China.

Genetics and Molecular Research : GMR
|July 1, 2015
PubMed

Insights

Continuous blood purification (CBP) effectively treats pediatric sepsis, significantly reducing disease severity and inflammation markers like YKL-40 and CRP. These markers can monitor treatment effectiveness in children with sepsis.

Area of Science:

  • Pediatric critical care medicine
  • Biomarker research
  • Sepsis pathophysiology

Background:

  • Sepsis is a life-threatening condition in children, characterized by systemic inflammation and organ dysfunction.
  • Identifying effective treatments and reliable biomarkers for pediatric sepsis is crucial for improving patient outcomes.
  • Continuous blood purification (CBP) is a potential therapeutic strategy for severe pediatric sepsis.

Purpose of the Study:

  • To evaluate the efficacy of CBP in treating severe pediatric sepsis.
  • To analyze the dynamic changes in inflammation markers, including cartilage glycoprotein 39 (YKL-40) and C-reactive protein (CRP), during CBP treatment.
  • To assess the correlation between YKL-40, CRP, and other inflammatory cytokines (IL-6, TNF-α) in pediatric sepsis.

Main Methods:

  • A cohort of 30 children with severe sepsis received CBP treatment.
  • Disease severity scores were assessed before and after CBP treatment.
  • Levels of Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), YKL-40, and CRP were measured at multiple time points (0, 12, 24, 48 hours) post-treatment.
  • YKL-40 mRNA expression was determined using biochemical and immunochemical methods.

Main Results:

  • CBP treatment led to a significant reduction in disease severity scores (P < 0.05).
  • Levels of IL-6, TNF-α, YKL-40, and CRP were significantly decreased at 12, 24, and 48 hours after CBP initiation compared to pre-treatment levels (P < 0.05).
  • Elevated YKL-40 mRNA expression was observed in sepsis patients before CBP treatment compared to controls (P < 0.05).
  • A positive correlation was found between IL-6, TNF-α, YKL-40, and CRP levels 48 hours post-CBP treatment.

Conclusions:

  • Continuous blood purification is an effective treatment for pediatric sepsis.
  • YKL-40 and CRP serve as valuable biomarkers for evaluating the effectiveness of sepsis treatment in children.
  • Monitoring these biomarkers can aid in clinical management and assessment of therapeutic response in pediatric sepsis.

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