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Hyperpolarizing action of cromakalim on the rat aorta
S A Doggrell1, J W Smith, O A Downing
1Department of Pharmaceutical Sciences, Aston University, Birmingham, U.K.
European Journal of Pharmacology
|December 12, 1989
Abstract:
Cromakalim alone at 1 microM had no effect and at 10 microM hyperpolarized the rat aorta. The rat aorta was depolarized by KCl (20 mM), noradrenaline (0.3 microM) and 5-hydroxytryptamine (1 microM). In the presence of depolarization with KCl, noradrenaline or 5-hydroxytryptamine, cromakalim at 1 and 10 microM hyperpolarized the rat aorta. Thus the antispasmogenic actions of modest concentrations of cromakalim is compatible with potassium channel opening.