Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

17.1K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
17.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and radiological distinctiveness of anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis-associated interstitial lung disease: a retrospective cohort study.

Scandinavian journal of rheumatology·2026
Same author

[Risk assessment of subsequent drug resistance in patients with chemoresistant gestational trophoblastic neoplasia].

Zhonghua fu chan ke za zhi·2026
Same author

[Current advances and challenges of immunotherapy in gestational trophoblastic neoplasia].

Zhonghua yi xue za zhi·2026
Same author

[Association between cosleeping and emotional-behavioral problems and its differences with or without sleep anxiety in preschool children].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2026
Same author

Fluorescent PSMA-Targeted Radiotheranostic Compounds for Multiscale Imaging.

Bioconjugate chemistry·2025
Same author

Efficacy and safety of biweekly single-dose actinomycin D versus multiday methotrexate in low-risk gestational trophoblastic neoplasia: a prospective multicenter randomized trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Related Experiment Video

Updated: Apr 8, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K

Partial least squares-based gene expression analysis in preeclampsia.

F Jiang1, Y Yang2, J Li3

  • 1Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China fjiang@fmmu.edu.cn.

Genetics and Molecular Research : GMR
|July 1, 2015
PubMed
Summary
This summary is machine-generated.

Preeclampsia, a major cause of maternal and fetal complications, has an unclear cause. This study identified key gene expression differences and hub genes in preeclampsia patients, offering insights for future therapies.

More Related Videos

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

11.7K
Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

11.5K

Related Experiment Videos

Last Updated: Apr 8, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K
Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

11.7K
Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

11.5K

Area of Science:

  • Genomics
  • Molecular Biology
  • Obstetrics

Background:

  • Preeclampsia poses significant risks to maternal and fetal health.
  • The underlying causes of preeclampsia remain largely unknown.
  • Understanding gene expression patterns is crucial for identifying preeclampsia mechanisms.

Purpose of the Study:

  • To identify differentially expressed genes in preeclampsia patients compared to healthy controls.
  • To uncover potential molecular pathways and hub genes associated with preeclampsia.
  • To provide a foundation for future therapeutic interventions in preeclampsia.

Main Methods:

  • Utilized partial least squares-based analysis for gene expression profiling.
  • Downloaded and analyzed gene expression data from the Gene Expression Omnibus (GEO) database.
  • Performed network analysis to identify significant hub genes.

Main Results:

  • Identified 503 differentially expressed genes (248 downregulated, 255 overexpressed).
  • Discovered 5 key hub genes: UBB, PIK3R1, MAPRE1, VEGFA, and ITGB1.
  • Confirmed associations of PIK3R1, VEGFA, and ITGB1 with preeclampsia or related processes.

Conclusions:

  • Preeclampsia exhibits distinct gene expression signatures.
  • Specific hub genes like PIK3R1, VEGFA, and ITGB1 are implicated in preeclampsia.
  • These findings offer valuable theoretical support for developing novel preeclampsia therapies.