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Spontaneous Murine Model of Anaplastic Thyroid Cancer

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Ameloblastic Carcinoma.

Dakshika Abeydeera Gunaratne¹, Hedley G Coleman², Lydia Lim³

¹Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, Sydney, Australia.

The American Journal of Case Reports

|July 2, 2015

Summary

Ameloblastic carcinoma, secondary type, an aggressive odontogenic neoplasm, can arise from untreated benign lesions. Radical surgical resection is crucial for managing this rare malignancy.

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Area of Science:

Oral pathology
Surgical oncology
Odontogenic neoplasms

Background:

Ameloblastic carcinoma, secondary type, is a rare, aggressive odontogenic neoplasm.
It typically arises from de-differentiation of pre-existing ameloblastoma or odontogenic cysts after repeated treatments.
Malignant transformation from an untreated benign lesion is exceptionally rare.

Observation:

A 66-year-old man presented with a newly diagnosed ameloblastic carcinoma.
The patient underwent hemimandibulectomy, supraomohyoid neck dissection, and free-flap reconstruction.
Histologic analysis confirmed de-differentiation, leading to a diagnosis of intraosseous ameloblastic carcinoma, secondary type.

Findings:

The case presented features of carcinomatous de-differentiation from an earlier, untreated benign lesion.
This represents a rare occurrence of secondary ameloblastic carcinoma development.
Histologic analysis confirmed the de-differentiated intraosseous nature of the tumor.

Implications:

Ameloblastic carcinoma, secondary type, poses a diagnostic challenge.
Radical surgical resection with wide margins is essential for curative treatment.
This case highlights the importance of recognizing malignant potential even in initially untreated benign odontogenic lesions.