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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Cerebrovascular Dysfunction in Preeclamptic Pregnancies

Erica Shields Hammer1, Marilyn J Cipolla

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT, USA, Erica.hammer@uvmhealth.org.

Current Hypertension Reports
|July 2, 2015
PubMed

Preeclampsia is a hypertensive, multisystem disorder of pregnancy that affects several organ systems, including the maternal brain. Cerebrovascular dysfunction during preeclampsia can lead to cerebral edema, seizures, stroke, and potentially maternal mortality. This review will discuss the effects of preeclampsia on the cerebrovasculature that may adversely affect the maternal brain, including cerebral blood flow (CBF) autoregulation and blood-brain barrier disruption and the resultant clinical outcomes including posterior reversible encephalopathy syndrome (PRES) and maternal stroke. Potential long-term cognitive outcomes of preeclampsia and the role of the cerebrovasculature are also reviewed.

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