Related Experiment Video
Updated: Aug 13, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Chronic atrophic acrodermatitis]
Dermatologische Monatschrift
|January 1, 1989
Summary
Acrodermatitis chronica atrophicans (ACA) patients exhibit diverse symptoms, responding to penicillin therapy. Borrelia antibody titers decline slowly, limiting their use for direct Lyme-borreliosis treatment monitoring.
Area of Science:
- Infectious Diseases
- Dermatology
- Rheumatology
Context:
- Acrodermatitis chronica atrophicans (ACA) is a late manifestation of Lyme borreliosis.
- Patients present with a wide array of cutaneous, arthritic, and neurologic symptoms.
- Systemic manifestations include altered protein levels, liver function tests, and electrocardiogram changes.
Purpose:
- To investigate the clinical presentation, diagnostic markers, and therapeutic response in patients with ACA.
- To evaluate the utility of indirect immunofluorescence assay for Borrelia antibody detection.
- To assess the effectiveness of penicillin therapy and the kinetics of antibody titers for treatment monitoring.
Summary:
- All 18 ACA patients tested positive for Borrelia antibodies via indirect immunofluorescence assay.
- Penicillin therapy resulted in clinical improvement, though Jarisch-Herxheimer reactions occurred in three patients.
- Borrelia antibody titers decreased slowly post-treatment, indicating they are not suitable for immediate therapy control.
Impact:
- Highlights the polysymptomatic nature of Lyme borreliosis, necessitating broader clinical awareness.
- Emphasizes the need for accessible, specific diagnostic tools for Lyme borreliosis nationwide.
- Suggests that while penicillin is effective, treatment monitoring requires methods beyond antibody titer assessment.
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...