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Related Experiment Videos

[Chronic atrophic acrodermatitis].

R Kosbab, G Thess, E Köstler

    Dermatologische Monatschrift
    |January 1, 1989
    PubMed
    Summary

    Acrodermatitis chronica atrophicans (ACA) patients exhibit diverse symptoms, responding to penicillin therapy. Borrelia antibody titers decline slowly, limiting their use for direct Lyme-borreliosis treatment monitoring.

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    [Hepatitis C, hemochromatosis and porphyria cutanea tarda].

    Deutsche medizinische Wochenschrift (1946)·2006

    Area of Science:

    • Infectious Diseases
    • Dermatology
    • Rheumatology

    Context:

    • Acrodermatitis chronica atrophicans (ACA) is a late manifestation of Lyme borreliosis.
    • Patients present with a wide array of cutaneous, arthritic, and neurologic symptoms.
    • Systemic manifestations include altered protein levels, liver function tests, and electrocardiogram changes.

    Purpose:

    • To investigate the clinical presentation, diagnostic markers, and therapeutic response in patients with ACA.
    • To evaluate the utility of indirect immunofluorescence assay for Borrelia antibody detection.
    • To assess the effectiveness of penicillin therapy and the kinetics of antibody titers for treatment monitoring.

    Summary:

    • All 18 ACA patients tested positive for Borrelia antibodies via indirect immunofluorescence assay.
    • Penicillin therapy resulted in clinical improvement, though Jarisch-Herxheimer reactions occurred in three patients.
    • Borrelia antibody titers decreased slowly post-treatment, indicating they are not suitable for immediate therapy control.

    Impact:

    • Highlights the polysymptomatic nature of Lyme borreliosis, necessitating broader clinical awareness.
    • Emphasizes the need for accessible, specific diagnostic tools for Lyme borreliosis nationwide.
    • Suggests that while penicillin is effective, treatment monitoring requires methods beyond antibody titer assessment.

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