Related Experiment Video
Updated: Apr 8, 2026
03:10
Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
Published on: November 1, 2024
3.9K
Acne inversa complicated by Actinomyces neuii
Jakob Nedomansky1, Doris Weiss2, Birgit Willinger3
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Infection
|July 2, 2015
Summary
This case study identifies Actinomyces neuii as a rare cause of recurring acne inversa (AI). Prompt antibiotic treatment for this infection led to sustained remission, highlighting the importance of diagnosing superinfections in AI management.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Acne inversa (AI) is a chronic inflammatory skin condition affecting intertriginous areas.
- AI is characterized by pain, drainage, malodor, and scarring, often involving secondary bacterial superinfections.
- The pathogenesis of AI is thought to involve autoimmune reactions, but superinfections play a significant role.
Observation:
- A unique case involved a 43-year-old male with a recurring AI lesion in the left axilla.
- A bacterial swab identified Actinomyces neuii as the sole pathogen in the lesion.
Findings:
- The patient received Amoxicillin/Clavulanic Acid, leading to lesion clearance and negative intraoperative swabs for A. neuii.
- Following a 4-week antibiotic course, the patient remained relapse-free for over 12 months post-surgical excision.
Implications:
- This case highlights the rare co-occurrence of AI and cutaneous Actinomycosis.
- Failure to identify slow-growing pathogens like Actinomyces spp. may increase AI recurrence rates, emphasizing the need for thorough infection workup before immunosuppressive therapy.
Related Concept Videos
01:27Acne Infection
58
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
58
01:27The Skin Microbiota
61
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
61
01:21Accessory Structures of the Skin: Sebaceous Glands
5.6K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.6K
01:29Staphylococcal Skin Infections
78
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
78
01:23Skin Diseases and Disorders
6.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.2K
01:30Bacterial Phylum Actinobacteria
865
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
865