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Published on: February 21, 2016
Whether or not to accept a deceased donor kidney offer for a pediatric patient
Abanti Chaudhuri1, Gerri James, Paul Grimm
1Department of Pediatric Nephrology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA, 94305-5208, USA, abanti@stanford.edu.
Insights
Pediatric kidney transplant waitlists are growing faster than organ availability. This review examines ethical considerations for transplant teams deciding whether to accept deceased donor kidneys for children.
Area of Science:
- Nephrology
- Transplantation
- Bioethics
Background:
- The demand for pediatric deceased donor renal transplants significantly exceeds organ supply globally.
- Organ allocation systems are country-specific, involving complex adjustments to optimize organ utilization and recipient outcomes.
Observation:
- Kidney offers are evaluated based on donor quality, human leukocyte antigen (HLA) matching, recipient factors, and geographic proximity.
- Transplant teams must make rapid decisions on organ acceptance, balancing competing ethical principles of equity and utility.
Findings:
- A representative case study illustrates the critical decision-making process for pediatric nephrologists.
- Key considerations include maximizing the benefit of scarce donor kidneys while ensuring equitable access.
Implications:
- This analysis provides insights for pediatric nephrologists facing complex ethical dilemmas in organ allocation.
- Optimizing deceased donor kidney utilization is crucial for improving pediatric renal transplant outcomes.
Abstract:
The expansion of the number of children on the deceased donor renal transplant waitlist has far outstripped the supply of organs in most countries, leading to numerous adjustments to increase supply and to maximize the utility of donor organs. The system for organ allocation varies by country based on local laws, priorities, and resources. Adjustments are made to optimize allocation, enhance post-transplant survival benefit, decrease unequal transplant access, and optimize utilization of donated kidneys. Allocation of deceased donor kidneys is based on several criteria; however, the final decision to accept or reject the offered kidney is made by the potential recipient's transplant team (surgeon/nephrologist). Several considerations including assessment of the donor quality, the human leukocyte antigen (HLA) match between the donor and the recipient, numerous recipient factors, the geographical location of the recipient, and the organ all affect the decision to accept the organ or not for a particular recipient. This decision must be made quickly, often on the spot. Maximizing the benefit from this scarce resource raises difficult ethical issues. The philosophies of equity and utility are often competing. In this manuscript, we highlight a representative case that helps to focus on important issues for the pediatric nephrologist to consider while making the decision to accept a deceased donor kidney offer for a particular pediatric patient.
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