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Updated: Apr 8, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
Published on: July 14, 2011
Human telomerase inhibitors from microbial source
Kalarikkal Gopikrishnan Kiran1, Muthusamy Palaniswamy, Jayaraman Angayarkanni
1Cancer Therapeutics Laboratory, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, India.
Abstract:
Telomerase enzyme inhibitors have gained attention of scientific field due to the specificity of action of telomerase based therapies. Some telomerase have good combinatorial action with certain DNA damaging drugs. Natural compounds isolated from microbes provide a new scope of screening and large scale production of telomerase inhibitors. This review emphasizes the biochemistry and mode of action of different types of telomerase inhibitors isolated from microbial sources. Also elaborates on classification of telomerase inhibitors based on their mode of action in cancer cells.
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