Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

33.9K
Overview
33.9K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

14.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
14.5K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

186
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
186
Neural Regulation01:37

Neural Regulation

45.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.0K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

The journal of allergy and clinical immunology. In practice·2023
Same author

A concept for integrated care pathways for atopic dermatitis-A GA<sup>2</sup> LEN ADCARE initiative.

Clinical and translational allergy·2023
Same author

Evaluation of patient-reported outcome measures for on-demand treatment of hereditary angioedema attacks and design of KONFIDENT, a phase 3 trial of sebetralstat.

Clinical and translational allergy·2023
Same author

Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning.

Frontiers in immunology·2023
Same author

Efficacy of Biologics in Patients with Allergic Severe Asthma, Overall and by Blood Eosinophil Count: A Literature Review.

Advances in therapy·2023
Same author

An updated review of pediatric autoimmune neuropsychiatric disorders associated with Streptococcus/pediatric acute-onset neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis: What the allergist should know.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2023

Related Experiment Video

Updated: Apr 8, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.9K

Neural Abnormalities in Nonallergic Rhinitis.

Jonathan A Bernstein1, Umesh Singh

  • 1Division of Immunology/Allergy Section, Department of Internal Medicine, University of Cincinnati College of Medicine, 3255 Eden Ave., ML#563 Suite 350, Cincinnati, OH, 45267, USA, Jonathan.Bernstein@uc.edu.

Current Allergy and Asthma Reports
|July 2, 2015
PubMed
Summary
This summary is machine-generated.

Airway irritants activate sensory nerves via Transient Receptor Potential (TRP) channels, leading to rhinitis. Targeting these TRP channels offers therapeutic potential for nonallergic rhinitis (NAR) and may link it to asthma.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

32.5K

Related Experiment Videos

Last Updated: Apr 8, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.9K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

32.5K

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Airway epithelial cells and solitary chemoreceptor cells possess sensory nerve endings that detect airborne irritants.
  • Activation of Transient Receptor Potential (TRP) channels (A1 and V1) on these nerve endings triggers local reflexes, releasing neuropeptides like substance P.
  • These neuropeptides can cause submucosal edema, congestion, and rhinitis by dilating blood vessels.

Purpose of the Study:

  • To explore the role of TRP channels in the pathogenesis of nonallergic rhinitis (NAR).
  • To investigate potential therapeutic strategies targeting TRP channels for NAR.
  • To examine the association between NAR and nonallergic asthma.

Main Methods:

  • Review of existing literature on TRP channel function in airway sensory nerves.
  • Analysis of therapeutic interventions targeting TRPV1 channels, such as capsaicin and azelastine.
  • Discussion of the united airway disease hypothesis and potential shared mechanisms with asthma.

Main Results:

  • Altered TRP channel expression or activity influences irritant responsiveness in the airways.
  • Desensitization of TRPV1 channels with agonists like capsaicin shows therapeutic effectiveness.
  • Azelastine and antimuscarinic agents like tiotropium may modulate TRPV1 activity and offer benefits in NAR.

Conclusions:

  • TRP channels are key players in NAR pathogenesis and represent potential therapeutic targets.
  • Dysautonomia may also contribute to NAR development.
  • The united airway disease hypothesis suggests a link between NAR and nonallergic asthma, potentially mediated by factors like free immunoglobulin light chains and microRNA alterations.