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Published on: August 13, 2013
Regulation of IgE Responses by γδ T Cells
Yafei Huang1, Zhifang Yang, Jessica McGowan
1Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA, huangy@njhealth.org.
Abstract:
Immunoglobulin E (IgE) antibodies play a crucial role in host defense against parasite infections. However, inappropriate IgE responses are also involved in the pathogenesis of allergic diseases. The generation of IgE antibodies is a tightly controlled process regulated by multiple transcription factors, cytokines, and immune cells including γδ T cells. Accumulating evidence demonstrates that γδ T cells play a critical role in regulating IgE responses; however, both IgE-enhancing and IgE-suppressive effects are suggested for these cells in different experimental systems. In this review, we examine the available evidence and discuss the role of γδ T cells in IgE regulation both in the context of antigen-induced immune responses and in the state of partial immunodeficiency.
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