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Related Experiment Video

Updated: Apr 8, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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LIF signaling in stem cells and development.

Kento Onishi1, Peter W Zandstra2

  • 1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G9.

Development (Cambridge, England)
|July 2, 2015
PubMed
Summary
This summary is machine-generated.

Leukemia inhibitory factor (LIF) is crucial for stem cell propagation and development. LIF signaling activates signal transducer and activator of transcription 3 (STAT3), impacting cell identity and homeostasis.

Keywords:
Interleukin-6 (IL-6) cytokineLeukemia inhibitory factorSTAT3

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Immunology

Background:

  • Leukemia inhibitory factor (LIF) belongs to the interleukin-6 (IL-6) cytokine family.
  • Members of the IL-6 family activate signal transducer and activator of transcription 3 (STAT3).
  • STAT3 influences stem and progenitor cell identity, proliferation, and cytoprotection.

Purpose of the Study:

  • To provide an overview of JAK-STAT signaling during development.
  • To focus on Leukemia inhibitory factor (LIF)-mediated JAK-STAT3 activation.
  • To highlight the role of LIF in stem cell propagation and developmental processes.

Main Methods:

  • Review of existing literature on LIF and JAK-STAT signaling.
  • Analysis of studies involving LIF pathway components.
  • Focus on mouse embryonic stem cell propagation models.

Main Results:

  • LIF supports the propagation of mouse embryonic stem cells.
  • LIF signaling is essential for development and homeostasis.
  • LIF-mediated JAK-STAT3 activation is a key developmental pathway.

Conclusions:

  • Leukemia inhibitory factor (LIF) plays a vital role in embryonic development and stem cell maintenance.
  • JAK-STAT3 signaling, particularly via LIF, is critical for cellular processes during development.
  • Understanding LIF-mediated signaling provides insights into developmental biology and homeostasis.