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Polymorphisms of MMP9 and TIMP2 in Patients with Varicose Veins

Atike Tekeli Kunt1, Selim Isbir2, Uzay Gormus3

  • 1Department of Cardiovascular Surgery, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey.

In Vivo (Athens, Greece)
|July 2, 2015
PubMed
Abstract

Insights

Genetic variations in TIMP2, specifically the -418 C allele, are linked to an increased risk of developing varicose veins. The GG genotype may offer protection against varicose vein formation.

Area of Science:

  • Genetics
  • Vascular Biology
  • Molecular Medicine

Background:

  • Genetic predisposition is a suspected factor in varicose vein development.
  • Matrix metalloproteinases (MMPs) degrade extracellular matrix (ECM), potentially affecting vein wall integrity.
  • Tissue inhibitors of MMPs (TIMPs) regulate MMP activity.

Purpose of the Study:

  • To investigate the association between matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinase 2 (TIMP2) gene polymorphisms and the risk of varicose veins.

Main Methods:

  • Genotyping of MMP9 (1562 C/T) and TIMP2 (418G/C) polymorphisms using PCR and RFLP.
  • Study included 63 patients with varicose veins and 70 healthy controls.

Main Results:

  • No significant difference in MMP9 allele or genotype frequencies between patients and controls.
  • The TIMP2 -418 C allele was associated with an increased risk of varicose vein formation (p=0.007).
  • The TIMP2 GG genotype was significantly more frequent in controls, suggesting a protective effect (OR=0.333, p=0.012).

Conclusions:

  • The TIMP2 -418 C allele is linked to increased susceptibility to varicose veins.
  • Individuals with the TIMP2 GG genotype may have a reduced risk of developing varicose veins.
Keywords:
Varicose veingene polymorphismmatrix metalloproteinase-9tissue inhibitor of matrix metalloproteinase-2venous insufficiency

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