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Updated: Apr 8, 2026
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
The role of leptin in the ventricular remodeling process and its mechanism
Guoxing Zuo1, Xinping Du1, Liuying Zheng1
1Department of Cardiology, Tianjin Fifth Central Hospital No. 41 Zhejiang Road, Tianjin 300450, P. R. China.
Objective:
This study aims to explore the role of leptin in the ventricular remodeling process and its mechanism in the diabetic rats' model.
Methods:
The diabetic SD rats model induced by streptozotocin was established. The SD rats were randomly divided into 4 groups: control group (20 rats treated with citric acid/sodium citrate buffer); M0 group (10 rats treated with physiological saline); M1 group (10 rats treated with 50 μg/kg LP); M2 group (10 rats treated with 100 μg/kg LP). Ang-II was detected by ELISA. The expression levels of LP and Ob-Rb were detected by RT-PCR. MAPK phosphorylation changes were detected by western blotting. Myocardial morphology was observed.
Results:
Compared with control group, the blood glucose concentration and Ang-II significantly increased in diabetic model groups (P < 0.01) and body weight decreased (P < 0.05). The expression levels of LP and Ob-Rb increased and heart function decreased in diabetic model groups.
Conclusions:
LP may be involved in the myocardial cell hypertrophy through the neuroendocrine system and associated with the JAK-STAT, Ras-Raf-MEK-MAPK and PI-3K signaling pathway, which provides a new concept for the pathogenesis of cardiac hypertrophy.
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