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Published on: June 13, 2018
Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study
Jiefeng Wang1, Hongtao Liu1, Xiaoyang Liu1
1Department of Spine Surgery, Yantaiyuhuangding Hospital Shangdong, China.
Objective:
Genetic factors play an important role in osteosarcoma (OS) etiology and fibroblast growth factor 2 (FGF2) gene single polymorphisms may be involved. The aim of this study was to test whether FGF2 variants are associated with susceptibility to OS in a Chinese population.
Methods:
A total of 151 subjects who were diagnosed as OS and 225 healthy age-matched controls were enrolled in the present study. Thers11737764 C/T SNP in FGF2 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs11737764 genotypes and OS susceptibility or severity.
Results:
The genotype frequencies of the FGF2 rs11737764 C/T polymorphism were 44.4% (CC), 50.3% (CT) and 5.3% (TT) in OS patients, and 55.6% (CC), 43.1% (CT) and 1.3% (TT) in controls. Rs11737764 C/T was found to be significantly associated with increased risk and OS no matter what genetic model was used.
Conclusion:
In conclusion, our data demonstrated the FGF2 SNP rs11737764 was significantly associated with increased osteosarcoma susceptibility in Chinese Han Population.
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