Related Experiment Video
Updated: Apr 8, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Comparison of two different sevoflurane expelling methods on emergence agitation in infants following sevoflurane
Yunliang Yang1, Tieying Song1, Hong Wang1
1Department of Anesthesiology, The First Hospital of Shijiazhuang 36 Fanxi Road, Chang'an District, Shijiazhuang 50011, Hebei Province, China.
Insights
Emergence agitation in infants after sevoflurane anesthesia was lower with a low fresh gas flow expelling method compared to decreasing sevoflurane concentration. This method reduces postoperative agitation and harm.
Area of Science:
- Anesthesiology
- Pediatric Surgery
Background:
- Emergence agitation is a common complication in pediatric anesthesia.
- Sevoflurane is frequently used for general anesthesia in infants.
- Optimizing anesthetic emergence is crucial for patient recovery.
Purpose of the Study:
- To compare the efficacy of two sevoflurane expelling methods on emergence agitation in infants.
- To evaluate the impact of anesthetic emergence strategies on postoperative behavior.
Main Methods:
- 100 infants (1-3 years) undergoing cleft lip/palate repair were randomized into two groups.
- Group N: Sevoflurane concentration decreasing expelling.
- Group D: Low fresh gas flow expelling. Postoperative outcomes were recorded.
Main Results:
- No significant differences in anesthesia or extubation times between groups.
- Group D showed lower postoperative agitation incidence and severity (P < 0.05).
- Group N exhibited higher blood pressure and heart rates during sevoflurane expelling (P < 0.05).
Conclusions:
- Low fresh gas flow sevoflurane expelling is associated with reduced emergence agitation in infants.
- Avoiding sevoflurane maintenance during expelling minimizes postoperative agitation and adverse effects.
- This finding supports optimizing anesthetic emergence protocols for pediatric patients.
Purpose:
To investigate the effects of two different inhalation anesthetic expelling methods on emergence agitation in infants following sevoflurane anesthesia.
Methods:
100 infants (1~3 years old) with cleft lip and palate and ASA classification I~II were randomized into two groups, a sevoflurane concentration decreasing expelling group (group n = 50 cases) and a low fresh gas flow expelling group (group D = 50 cases). The operation for cleft lip and palate repair was under general anesthesia, in which 30 minutes after initiation of narcosis ending extubation was indicated and after the tubes were removed the patients were sent to the post-anesthesia care unit (PACU) to record anesthesia times, emergence agitation scores, Ramsay scores and adverse reactions including drowsiness, respiratory depression, nausea and vomiting, chills, hiccough or laryngospasms.
Results:
There were no differences in anesthesia times, awaking time and time until extubation between the two groups. 10 min after start of expelling sevoflurane, blood pressure and heart rates were higher in group N than in group D (P < 0.05). The postoperative agitation incidence and the degree of agitation were lower in group D than in group N (P < 0.05).
Conclusion:
Postoperative agitation is prone to occur in patients with sevoflurane concentration decreasing expelling. Avoiding sevoflurane application maintenance in the stage of sevoflurane expelling reduces the occurrence of postoperative agitation and diminishes physiological and psychological harm.
More Related Videos
03:02Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
Published on: July 25, 2025
04:55Administration of Volatile Anesthetics to Zebrafish Larvae for Behavioral Observation
Published on: June 6, 2025
Related Concept Videos
Inhalational Anesthetics: Overview
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia
Endotracheal Intubation II: Nursing Management
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
Drug Dosing: Infants and Children