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Insulin secretion and tolerance of women with different gestational glucose regulation one year postpartum

Jinhua Wei1, Xiaona Li2, Jianbo Gao2

  • 1Department of Obstetrics, Changzhou Second People's Hospital No. 29 Xinglong Alley, Changzhou 213003, China.

International Journal of Clinical and Experimental Medicine
|July 2, 2015
PubMed

Glucose intolerance during pregnancy is defined as gestational diabetes mellitus (GDM). 95 women after 1 year birth were divided into GDM (n = 22), GIGT (gestational impaired glucose tolerance, n = 41) and NGT (normal, n = 32) groups. The GIGT group was subdivided into GIGT1 (abnormal blood glucose in 1 h, n = 11), GIGT2 (in 2 h, n = 18) and GIGT3 (in 3 h, n = 12) after oral glucose tolerance tests (OGTT). Compared with GIGT and NGT groups, GDM group showed higher FBG, 75 g OGTT 2 h BG, HOMA-IR, BMI, TCH, TG and LDL-C levels, while lower IFI. GIGT group had higher 75 g OGTT 2 h BG and BMI than NGT. IFI level was the lowest, while HOMA-IR the highest in GIGT1 subgroup. GDM women are more susceptible to impaired insulin secretion, insulin tolerance and dyslipidemia. Women in GIGT1 subgroup may tend to developing DM.

Keywords:
Diabetes mellitusgestationalinsulinoral glucose tolerance testpostpartum

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