Association between serum carcinoembryonic antigen level and oxidative stress parameters among diabetic females

In this study we intended to determine serum level of the carcinoembryonic antigen (CEA) and to find out the correlation with oxidative stress parameters among diabetic female in comparison to control subjects.

A total of 120 Saudi (type 2 diabetic "T2DM", n = 60 and healthy non-diabetic, n = 60) nonsmokers females were enrolled in this study. Body mass index (BMI) was estimated using weight and height; CEA, superoxide dismutase (SOD), 8-hydroxy-deoxyguanosine (8-OHDG), malondialdehyde (MDA) were performed using enzyme-linked immunosorbent assay (ELISA) kits. Blood glucose was estimated by GOD/POD method and, glycated haemoglobin (HbA1c) by immunoturbidimetric method.

The student's t-test showed significant differences between the diabetics and controls in CEA, blood glucose, age, oxidative stress markers. Moreover, Pearson's correlation coefficient (r) indicated significant correlations between CEA and age, BMI, blood glucose, HbA1, and MDA. No significant correlation was found between CEA and 8-OHdG, SOD.

In this study we confirmed that CEA influence with components of type 2 diabetes and glycemic control. We found correlation between Lipid peroxidation and CEA among diabetic female in comparison to control subjects.