Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
Stem Cell Culture01:17

Stem Cell Culture

6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.0K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.3K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.3K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.6K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Global Consensus on Keratoconus 2: From Definitions to Decision Making.

Cornea·2026
Same author

Reliability of a Scheimpflug-based tomographer compared with a Placido-based topographer and specular microscopy in healthy eyes.

Arquivos brasileiros de oftalmologia·2026
Same author

Oral riboflavin supplementation and sunlight exposure: A possible novel and accessible approach to stabilize progressive keratoconus.

European journal of ophthalmology·2026
Same author

The Gut Microbiome in Stevens-Johnson Syndrome and Sjögren's Disease: Correlations with Dry Eye.

Microorganisms·2025
Same author

Tear-Film Stability After Upper Blepharoplasty with Fractional CO<sub>2</sub> Laser: A Retrospective 5-Month Series.

Photobiomodulation, photomedicine, and laser surgery·2025
Same author

Chronic Ocular Complications in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Clinical Features and Surgical Management in a Brazilian Tertiary Center.

Cornea·2025

Related Experiment Video

Updated: Apr 8, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea
07:35

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

9.4K

Corneal stem cells and tissue engineering: Current advances and future perspectives.

Aline Lütz de Araujo1, José Álvaro Pereira Gomes1

  • 1Aline Lütz de Araujo, Clínica Lentecor, Porto Alegre - RS 90570041, Brazil.

World Journal of Stem Cells
|July 2, 2015
PubMed
Summary

Regenerative medicine advances corneal stem cell therapies for transplantation. Challenges remain for corneal epithelial, stromal, and endothelial cell applications, but potential for scar repair and tissue engineering is high.

Keywords:
Cell-based therapyCorneaCorneal endotheliumLimbal transplantationStem cellsTissue engineering

More Related Videos

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

13.0K
Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

8.5K

Related Experiment Videos

Last Updated: Apr 8, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea
07:35

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

9.4K
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

13.0K
Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

8.5K

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Corneal transplantation is the current standard for treating corneal blindness.
  • Stem cell-based therapies offer a promising alternative to conventional corneal transplantation.
  • Each layer of the cornea presents unique challenges for regenerative approaches.

Purpose of the Study:

  • To review current data on corneal epithelial stem cells, stromal stem cells, and endothelial cell progenitors.
  • To discuss recent advances and future perspectives in corneal regenerative medicine.
  • To highlight challenges and potential therapeutic applications of corneal stem cells.

Main Methods:

  • Review of existing literature on corneal stem cell research.
  • Analysis of clinical data from corneal limbal autografts.
  • Discussion of in vitro and in vivo studies on corneal stem cell behavior and potential.

Main Results:

  • Corneal limbal autografts show high success rates for epithelial stem cell transplantation.
  • Corneal endothelial cells possess self-renewal capacity but limited in vivo proliferation.
  • Human corneal stromal stem cells show potential for scar repair and tissue engineering.

Conclusions:

  • Stem cell therapies hold significant promise for corneal regenerative medicine.
  • Further research is needed to overcome challenges in endothelial cell transplantation and stromal engineering.
  • Advances in ex vivo cultures and cell delivery methods are crucial for future success.