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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

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Histone deacetylases and cardiovascular cell lineage commitment

Jun-Yao Yang1, Qian Wang1, Wen Wang1

  • 1Jun-Yao Yang, Qian Wang, Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.

World Journal of Stem Cells
|July 2, 2015
PubMed

Insights

Histone deacetylases (HDACs) regulate genes involved in cardiovascular diseases. This review explores how HDACs and their inhibitors impact stem cell differentiation for potential cardiovascular therapies.

Area of Science:

  • Cardiovascular biology
  • Epigenetics
  • Stem cell therapy

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of death, linked to inflammation, lipid disorders, and endothelial dysfunction.
  • Stem cell therapy is emerging as a promising treatment for CVDs, aiming to regenerate damaged heart and vascular tissues.
  • Histone deacetylases (HDACs) are epigenetic regulators crucial for biological processes, including cardiovascular health, by influencing vascular cell homeostasis.

Purpose of the Study:

  • To review the roles of various HDACs in cardiovascular diseases.
  • To examine the impact of HDAC inhibitors on stem/progenitor cell differentiation into vascular lineages.
  • To discuss the therapeutic potential of targeting HDACs in CVD treatment.

Main Methods:

  • Literature review focusing on HDACs, stem cells, and cardiovascular disease.
  • Analysis of studies investigating HDACs' function in endothelial cells, smooth muscle cells, and cardiomyocytes.
  • Exploration of research on HDAC inhibitors' effects on stem cell differentiation.

Main Results:

  • HDACs play critical roles in modulating vascular cell proliferation, migration, and apoptosis.
  • HDACs influence stem and progenitor cell differentiation towards endothelial cells, smooth muscle cells, and cardiomyocytes.
  • HDAC inhibitors show potential in directing stem cell differentiation for cardiovascular regeneration.

Conclusions:

  • HDACs are significant epigenetic regulators in cardiovascular pathophysiology.
  • Targeting HDACs offers a novel therapeutic strategy for CVDs by leveraging stem cell differentiation.
  • Further research into HDAC inhibitors could unlock new avenues for regenerative cardiovascular medicine.

Keywords:
Cardiovascular diseasesEndothelial cellHistone deacetylasesSmooth muscle cellStem cell

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