Related Experiment Video
Updated: Apr 8, 2026
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Clinical characteristics of ceftriaxone plus metronidazole in complicated intra-abdominal infection
1Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
Purpose:
Empirical antibiotics in complicated intra-abdominal infection (c-IAI), such as secondary peritonitis are a first step of treatment. Empirical antibiotic regimen is very diverse. Ceftriaxone plus metronidazole regimen (CMR) is one of the empirical antibiotic regimens used in treatment of c-IAI. However, although CMR is a widely used empirical antibiotic regimen, study regarding success, failure or efficacy of CMR has been poorly understood. This retrospective study is conducted to compare the clinical efficacy of this regimen in c-IAI according to clinical characteristics.
Methods:
The subjects were patients in this hospital who were diagnosed as secondary peritonitis between 2009 and 2013. Retrospective analysis was performed based on the records made after surgery regarding clinical characteristics including albumin level, blood pressure, pulse rate, respiration rate, smoking, age, sex, body mass index, hemoglobin, coexisting disease, leukocytosis, and APACHE (acute physiology and chronic health evaluation) II score.
Results:
A total of 114 patients were enrolled. In univariated analysis, the success and failure of CMR showed significant association with preoperative low albumin, old age, and preoperative tachycardia. In multivariated analysis, low albumin and preoperative tachycardia were significant.
Conclusion:
It is thought that an additional antibiotic treatment plan is necessary in patients with low albumin and tachycardia when the empirical antibiotic regimen is CMR in c-IAI. Conduct of research through well-designed prospective randomized clinical study is also necessary in order to evaluate the appropriateness of CMR and decide on a proper empirical antibiotic regimen between many regimens in c-IAI based on our country.
Insights
Ceftriaxone plus metronidazole regimen (CMR) efficacy in complicated intra-abdominal infections (c-IAI) is linked to low albumin and tachycardia. Patients with these factors may need additional antibiotic treatment plans for better outcomes.
Area of Science:
- Infectious Diseases
- Clinical Pharmacology
- Surgical Infections
Background:
- Complicated intra-abdominal infections (c-IAI), including secondary peritonitis, are initially treated with empirical antibiotics.
- Ceftriaxone plus metronidazole regimen (CMR) is a common empirical choice, but its clinical efficacy and failure predictors remain unclear.
- Understanding factors influencing CMR success is crucial for optimizing treatment strategies in c-IAI.
Purpose of the Study:
- To retrospectively evaluate the clinical efficacy of the ceftriaxone plus metronidazole regimen (CMR) in patients with complicated intra-abdominal infections (c-IAI).
- To identify clinical characteristics associated with the success or failure of CMR in treating secondary peritonitis.
Main Methods:
- Retrospective analysis of 114 patients diagnosed with secondary peritonitis between 2009 and 2013.
- Collected clinical data included albumin levels, vital signs, demographics, comorbidities, and APACHE II scores.
- Univariate and multivariate analyses were performed to identify predictors of CMR treatment outcomes.
Main Results:
- Low preoperative albumin and preoperative tachycardia were significantly associated with CMR treatment failure in both univariate and multivariate analyses.
- Old age was also associated with treatment failure in the univariate analysis.
- These findings highlight specific patient factors impacting the effectiveness of empirical CMR.
Conclusions:
- Patients receiving CMR for c-IAI with low albumin and tachycardia may require adjusted or additional antibiotic therapy.
- Further well-designed prospective studies are needed to confirm these findings and guide the selection of optimal empirical antibiotic regimens for c-IAI.
More Related Videos
Related Concept Videos
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
01:28Inhibitors of Bacterial DNA Synthesis
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:27Combined Effects of Drugs: Synergism
Such synergistic combinations...
01:26Urinary Tract Infection I: Introduction
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents