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Mouse Hepatic Tumor Vascular Imaging by Experimental Selective Angiography
Sang Kyum Kim1, Honsoul Kim2, Gou Young Koh3
1Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Plos One
|July 2, 2015
Summary
Selective latex angiography in mouse models revealed vascular characteristics mimicking human hepatocellular carcinoma (HCC). This technique is crucial for evaluating liver tumor models in translational research.
Area of Science:
- Hepatobiliary research
- Oncology
- Vascular imaging
Background:
- Human hepatocellular carcinoma (HCC) exhibits distinct vascular features requiring specialized imaging.
- Mouse models often lack the necessary vascular detail for accurate HCC evaluation due to small vessel size.
- Understanding tumor vascularization is critical for effective hepatic tumor modeling.
Purpose of the Study:
- To perform selective latex angiography in various mouse liver tumor models.
- To assess the suitability of these models for mimicking human HCC vascularization.
Main Methods:
- Utilized ectopic (Lewis lung carcinoma, B16/F10 melanoma) and spontaneous (genetically modified mice) liver tumor models.
- Administered latex dye via cardiac left ventricle and/or portal vein puncture for selective arteriography and/or portography.
- Examined perfusion patterns in H-ras12V transgenic mice, revealing intra-tumoral vascular heterogeneity.
Main Results:
- H-ras12V transgenic mice displayed varied perfusion patterns (portal venous, hepatic artery, or mixed).
- Selective latex angiography in Lewis lung carcinoma and Albumin-Cre/WW45fl/fl models replicated human HCC angiography findings.
- These models showed tumors with prominent feeding arteries and absent portal venous perfusion.
Conclusions:
- Mouse liver tumor models exhibit diverse vascular characteristics impacting their translational suitability.
- Selective latex angiography in specific mouse models accurately simulates human HCC vascular imaging.
- Model selection should consider vascular characteristics for effective translational studies.
