Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex
Arup Mukherjee1, Dipankar Srimani1, Subrata Chakraborty1
1Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract:
The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.
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