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Updated: Apr 7, 2026

A Protocol for Housing Mice in an Enriched Environment

A Protocol for Housing Mice in an Enriched Environment

Published on: June 8, 2015

A Protocol for Housing Mice in an Enriched Environment.

Andrew M Slater¹, Lei Cao²

¹Department of Molecular Virology, Immunology, and Medical Genetics, and Comprehensive Cancer Center, The Ohio State University.

Journal of Visualized Experiments : Jove

|July 2, 2015

Summary

Environmental enrichment (EE) improves mouse health by reducing obesity and aiding cancer remission. Proper setup and maintenance of EE are crucial for reproducible research findings.

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Area of Science:

Animal models
Laboratory housing
Environmental enrichment

Background:

Environmental enrichment (EE) housing enhances mouse mental and physical health compared to standard housing.
EE has demonstrated benefits including decreased adiposity, increased energy expenditure, resistance to diet-induced obesity, and cancer remission/inhibition in mice.

Purpose of the Study:

To demonstrate the proper setup and maintenance of environmental enrichment (EE).
To ensure a complex, challenging, and controlled environment for reproducible research.
To facilitate the replication of EE's protective effects against obesity and cancer.

Main Methods:

Utilizing larger living spaces with varied 'toys' and running wheels.
Implementing regular changes in toy location and type to foster adaptation to novel environments.
Controlling multiple variables within the EE setup to ensure consistent and reproducible phenotypes.

Main Results:

EE housing leads to reduced adiposity and increased energy expenditure in mice.
Environmental enrichment demonstrates efficacy in resisting diet-induced obesity.
EE promotes cancer remission and inhibition in mouse models.

Conclusions:

Properly managed environmental enrichment is essential for achieving reproducible health benefits in mice.
Standardized EE protocols can be established to reliably reproduce protective effects against obesity and cancer.
This demonstration provides a framework for researchers to implement controlled EE for scientific advancement.