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Self-assembling bubble carriers for oral protein delivery.

Er-Yuan Chuang1, Kun-Ju Lin2, Po-Yen Lin1

  • 1Department of Chemical Engineering and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.

Biomaterials
|July 2, 2015
PubMed
Summary

This study developed a novel bubble carrier system for oral insulin delivery. The system protects insulin and enhances its absorption, offering a promising alternative for diabetic patients.

Keywords:
BiodistributionColloidal carrierFoaming agentOral protein deliverySurfactant

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Oral delivery of therapeutic proteins like insulin is challenging due to degradation in the gastrointestinal tract.
  • Improving protein drug bioavailability requires strategies to protect against enzymatic breakdown and enhance mucosal permeability.

Purpose of the Study:

  • To develop and evaluate a novel bubble carrier system for oral insulin delivery.
  • To investigate the mechanism of insulin release and absorption facilitated by the bubble carrier system.

Main Methods:

  • An enteric-coated gelatin capsule was formulated with diethylene triamine pentaacetic acid dianhydride, sodium bicarbonate (foaming agent), sodium dodecyl sulfate (surfactant), and insulin.
  • The system was administered orally to diabetic rats to assess insulin release and absorption.
  • CO2 bubble formation and growth dynamics were analyzed in response to intestinal conditions.

Main Results:

  • The bubble carrier system successfully generated CO2 bubbles in the acidic intestinal environment.
  • The bubbles acted as colloidal carriers for insulin and diethylene triamine pentaacetic acid.
  • Released diethylene triamine pentaacetic acid and sodium dodecyl sulfate protected insulin and enhanced its absorption, leading to hypoglycemic effects in rats.

Conclusions:

  • The developed bubble carrier system demonstrates potential for effective oral insulin delivery.
  • This innovative approach enhances insulin stability and absorption, offering a non-invasive therapeutic option for diabetes management.