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Complement phenotypes in patients with psoriasis.

R J Wyatt1, C Wang, E C Hudson

  • 1Department of Pediatrics, University of Tennessee, Memphis.

Human Heredity
|January 1, 1989
PubMed
Summary
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The C4*A6 allele, linked to HLA B17, is significantly more common in Caucasian psoriasis patients than controls, suggesting a genetic link to psoriasis development. This finding highlights complement system variations in the disease.

Area of Science:

  • Immunogenetics
  • Dermatology
  • Human Genetics

Background:

  • Psoriasis is a chronic inflammatory skin disease with a complex genetic component.
  • Complement system proteins, including C4A, C4B, factor B (Bf), and C3, play roles in immune responses.
  • Previous studies suggest associations between certain Human Leukocyte Antigen (HLA) alleles and psoriasis.

Purpose of the Study:

  • To investigate the phenotype frequencies of complement proteins C4A, C4B, Bf, and C3 in Caucasian patients with psoriasis.
  • To determine if specific complement protein alleles are associated with psoriasis in this population.
  • To explore the relationship between complement protein alleles and known psoriasis-associated HLA alleles.

Main Methods:

  • Phenotype frequencies of complement proteins C4A, C4B, Bf, and C3 were analyzed.

Related Experiment Videos

  • A cohort of 49 Caucasian patients with psoriasis was compared to healthy Caucasian controls.
  • Statistical analysis, including relative risk calculation, was performed to assess associations.

    • Main Results:

    • The C4*A6 allele was found in 26.6% of psoriasis patients versus 5.4% of controls (p < 0.001, RR = 6.28).
    • A significant reduction in the C4B*2 allele frequency was observed in patients.
    • No significant differences were found for Bf or C3 phenotype frequencies; a non-significant increase in Bf*F was noted.

    Conclusions:

    • The C4*A6 allele, known to be in linkage disequilibrium with HLA B17 (associated with psoriasis), shows a strong association with psoriasis in Caucasian individuals.
    • Complement C4B*2 allele deficiency may also be associated with psoriasis.
    • These findings suggest that specific complement protein gene polymorphisms, particularly C4A variants, contribute to psoriasis susceptibility.