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Updated: Apr 7, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
PROGRESSION OF AGE-RELATED MACULAR DEGENERATION OVERLYING A LARGE CHOROIDAL VESSEL
Maiko Inoue1, Kunal K Dansingani, K Bailey Freund
1*Vitreous Retina Macula Consultants of New York, New York, NY; †The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY; and ‡Department of Ophthalmology, New York University School of Medicine, New York, NY.
Purpose:
To describe a patient who showed progression of age-related macular degeneration along the course of an underlying large choroidal vessel.
Methods:
Retrospective case report.
Results:
An 84-year-old woman was diagnosed with age-related macular degeneration and followed for more than 6 years. Retinal pigment epithelial changes were more advanced in her right eye which had a thinner choroid than the fellow left eye. Multimodal imaging with swept-source optical coherence tomography showed that the progression of outer retinal and retinal pigment epithelial changes appeared to follow the course of a large choroidal vessel.
Conclusion:
The authors hypothesize that large choroidal vessels can compress the overlying choriocapillaris, possibly leading to outer retinal ischemia, which subsequently could focally accelerate the course of age-related macular degeneration.
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