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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Association between Ophthalmological Changes and Cardiovascular Diseases in Patients with Chronic Kidney Disease

Hirohiko Nokiba1, Takashi Takei, Chikako Suto

  • 1Department of Medicine, Kidney Center, Tokyo Women's Medical University.

Journal of Atherosclerosis and Thrombosis
|July 3, 2015
PubMed

Insights

Retinal arterial sclerosis, assessed by the Scheie S grade, is linked to arterial stiffness and cardiovascular disease (CVD) history in hemodialysis patients. This retinopathy classification may help predict CVD risk in chronic kidney disease patients.

Area of Science:

  • Ophthalmology
  • Nephrology
  • Cardiology

Background:

  • Patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) have a high prevalence of cardiovascular diseases (CVD).
  • Arterial sclerosis is a key factor in CVD development.
  • The association between retinal arterial sclerosis and CVD in CKD patients on HD remains understudied.

Purpose of the Study:

  • To assess retinal arterial sclerosis in patients with CKD on HD.
  • To investigate the relationship between retinal arterial changes and arterial stiffness.
  • To explore the link between retinal arterial changes and a past history of CVD.

Main Methods:

  • Data from 44 CKD patients on HD were analyzed.
  • Ophthalmological findings, including Scheie classification of retinopathy, were evaluated.
  • Arterial stiffness (pulse wave velocity) and past CVD history were assessed; medications and biochemical parameters were recorded.

Main Results:

  • A significant correlation was observed between arteriosclerotic retinopathy (Scheie S grade) and arterial stiffness (p=0.001).
  • The presence of arteriosclerotic retinopathy was also significantly associated with a past history of CVD (p=0.045).
  • No other ophthalmological findings correlated with arterial stiffness or CVD history.

Conclusions:

  • Retinopathy classification, specifically the Scheie S grade, may serve as a useful indicator for predicting arterial stiffness.
  • Ophthalmoscopic examination of retinopathy can help identify patients at higher risk for arterial stiffness and associated CVD.
  • This study highlights a potential non-invasive method for risk stratification in CKD patients on HD.
Abstract

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