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Effect of selective estrogen receptor modulators on metabolic homeostasis

Beibei Xu1, Dragana Lovre1, Franck Mauvais-Jarvis1

  • 1Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, USA.

Biochimie
|July 3, 2015
PubMed

Insights

Selective estrogen receptor modulators (SERMs) impact metabolic homeostasis. This review covers how SERMs and tissue-selective estrogen complexes (TSECs) affect metabolic disorders in women and animal models.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Metabolic research

Background:

  • Selective estrogen receptor modulators (SERMs) are ligands targeting estrogen receptors (ER), showing tissue-specific agonist or antagonist activity.
  • Tamoxifen and raloxifene (first/second-gen SERMs) treat breast cancer and osteoporosis.
  • Bazedoxifene (BZA), a third-gen SERM, prevents osteoporosis while blocking estrogenic effects in breast/uterus.

Purpose of the Study:

  • To summarize current knowledge on the impact of SERMs on metabolic homeostasis.
  • To review the effects of SERMs and tissue-selective estrogen complexes (TSECs) on metabolic disorders.

Main Methods:

  • Literature review of studies on SERMs and metabolic homeostasis.
  • Analysis of data from animal models and postmenopausal women.

Main Results:

  • SERMs and TSECs are investigated for their effects on metabolic homeostasis.
  • Postmenopausal estrogen deficiency is linked to metabolic syndrome and type 2 diabetes.

Conclusions:

  • The role of SERMs and TSECs in metabolic health is an emerging area of research.
  • Understanding these effects is crucial for managing postmenopausal health and metabolic disorders.
Keywords:
BazedoxifeneDiabetesEnergy metabolismMetabolic syndromeSelective estrogen receptor modulatorsTissue-selective estrogen complex

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