Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phasor EO-FLIM: Lifetime imaging with picosecond noise and 500 Hz frame rate.

bioRxiv : the preprint server for biology·2026

Same author

Fast wide-field light sheet electro-optic FLIM.

Optics express·2026

Same author

Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin.

Bioengineering (Basel, Switzerland)·2024

Same author

Wide-field fluorescence lifetime imaging of neuron spiking and subthreshold activity in vivo.

Science (New York, N.Y.)·2023

Same author

An optical design enabling lightweight and large field-of-view head-mounted microscopes.

Nature methods·2023

Same author

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

PLoS biology·2022

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Apr 7, 2026

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Published on: March 21, 2014

Note: A single-chamber tool for plasma activation and surface functionalization in microfabrication.

Adam J Bowman¹, Joseph R Scherrer¹, Ronald S Reiserer¹

¹Vanderbilt Institute for Integrative Biosystems Research and Education and Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA.

The Review of Scientific Instruments

|July 3, 2015

Summary

This study introduces a new apparatus for enhanced surface modification of polydimethylsiloxane (PDMS) microfluidic devices. The single-chamber system improves surface quality and reduces degradation compared to traditional multi-chamber methods.

More Related Videos

Plasma Lithography Surface Patterning for Creation of Cell Networks

Plasma Lithography Surface Patterning for Creation of Cell Networks

Published on: June 14, 2011

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

Related Experiment Videos

Last Updated: Apr 7, 2026

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Published on: March 21, 2014

Plasma Lithography Surface Patterning for Creation of Cell Networks

Plasma Lithography Surface Patterning for Creation of Cell Networks

Published on: June 14, 2011

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

Area of Science:

Materials Science
Microfluidics Engineering
Surface Chemistry

Background:

Polydimethylsiloxane (PDMS) is widely used in microfluidic devices.
Surface modification is crucial for PDMS device functionality.
Existing methods often suffer from time-dependent degradation and surface irregularities.

Purpose of the Study:

To develop a simplified apparatus for improved surface modification of PDMS microfluidic devices.
To minimize time-dependent degradation of surface activation.
To enhance surface quality and reduce deposition irregularities.

Main Methods:

A single treatment chamber integrating plasma activation and vapor deposition.
Conducting plasma activation and treatment within the same vacuum environment.
Utilizing an inductively coupled plasma driver with interchangeable chambers.
Atomic force microscopy (AFM) for surface analysis.

Main Results:

The single-chamber apparatus minimizes time-dependent degradation of surface activation.
Reduced contamination and deposition irregularities compared to multi-chamber techniques.
Silane deposition on PDMS using this method yields significantly better surface quality.
AFM confirmed lower local roughness and fewer irregularities on treated PDMS surfaces.

Conclusions:

The presented apparatus offers a more robust and efficient method for PDMS surface modification.
This technique leads to superior surface quality, crucial for advanced microfluidic applications.
The simplified, single-chamber design addresses limitations of conventional multi-chamber approaches.