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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Allergen immunotherapy: what's new, what's next?
1National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
Abstract:
Although three sublingual immunotherapy tablets have been approved in the USA and more are under study, it is not clear that sublingual immunotherapy tablets will answer the needs of many patients in the USA, and this is due to the limited number of allergens that will be offered. Alternatives that employ off-label, currently available extracts hold the greatest likelihood of entering the US allergy practice. Those approaches that employ recombinant technology to produce hypoallergenic products face a long and expensive pathway to approval. Which of the many approaches under study will make it to the market is presently not clear.
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