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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

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Kidney diseases and tissue engineering

Kyung Hyun Moon1, In Kap Ko2, James J Yoo2

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA; Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Methods (San Diego, Calif.)
|July 3, 2015
PubMed

Insights

Kidney disease, including acute kidney injury (AKI) and chronic kidney disease (CKD), poses a global health challenge. Regenerative medicine and tissue engineering offer promising cell-based therapies to restore kidney function, overcoming limitations of current treatments.

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Kidney disease is a significant global public health issue with limited treatment options like dialysis and transplantation.
  • Acute kidney injury (AKI) can progress to chronic kidney disease (CKD) and end-stage renal disease (ESRD), often with high mortality.
  • Current treatments face challenges including donor organ scarcity, graft failure, and complications.

Purpose of the Study:

  • To review the fundamental components required for successful renal tissue engineering.
  • To present recent advancements in tissue engineering (TE) and regenerative medicine (RM) for treating kidney diseases.
  • To explore cell-based therapeutic strategies for restoring kidney function.

Main Methods:

  • Review of current literature on renal tissue engineering and regenerative medicine.
  • Discussion of cell therapy approaches using stem cells and primary kidney cells.
  • Analysis of basic components essential for developing functional renal tissue replacements.

Main Results:

  • Cell therapy using stem cells and primary kidney cells shows promise in restoring renal functions in AKI and CKD.
  • Tissue engineering for renal applications is progressing steadily, despite the kidney's complex structure and function.
  • Regenerative medicine and TE offer potential solutions to overcome limitations of conventional kidney disease treatments.

Conclusions:

  • Cell-based approaches in tissue engineering and regenerative medicine are vital for addressing the global burden of kidney disease.
  • These innovative strategies hold significant potential for restoring kidney function and improving patient outcomes.
  • Further research and development in renal TE and RM are crucial for clinical translation.
Keywords:
3D kidney constructsAcute and chronic kidney diseaseESRDKidney diseaseTissue engineeringWhole kidney engineering

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