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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Renal Corpuscle01:20

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Nephrons01:10

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Updated: Apr 7, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

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Kidney diseases and tissue engineering.

Kyung Hyun Moon1, In Kap Ko2, James J Yoo2

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA; Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Methods (San Diego, Calif.)
|July 3, 2015
PubMed
Summary
This summary is machine-generated.

Kidney disease, including acute kidney injury (AKI) and chronic kidney disease (CKD), poses a global health challenge. Regenerative medicine and tissue engineering offer promising cell-based therapies to restore kidney function, overcoming limitations of current treatments.

Keywords:
3D kidney constructsAcute and chronic kidney diseaseESRDKidney diseaseTissue engineeringWhole kidney engineering

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Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Kidney disease is a significant global public health issue with limited treatment options like dialysis and transplantation.
  • Acute kidney injury (AKI) can progress to chronic kidney disease (CKD) and end-stage renal disease (ESRD), often with high mortality.
  • Current treatments face challenges including donor organ scarcity, graft failure, and complications.

Purpose of the Study:

  • To review the fundamental components required for successful renal tissue engineering.
  • To present recent advancements in tissue engineering (TE) and regenerative medicine (RM) for treating kidney diseases.
  • To explore cell-based therapeutic strategies for restoring kidney function.

Main Methods:

  • Review of current literature on renal tissue engineering and regenerative medicine.
  • Discussion of cell therapy approaches using stem cells and primary kidney cells.
  • Analysis of basic components essential for developing functional renal tissue replacements.

Main Results:

  • Cell therapy using stem cells and primary kidney cells shows promise in restoring renal functions in AKI and CKD.
  • Tissue engineering for renal applications is progressing steadily, despite the kidney's complex structure and function.
  • Regenerative medicine and TE offer potential solutions to overcome limitations of conventional kidney disease treatments.

Conclusions:

  • Cell-based approaches in tissue engineering and regenerative medicine are vital for addressing the global burden of kidney disease.
  • These innovative strategies hold significant potential for restoring kidney function and improving patient outcomes.
  • Further research and development in renal TE and RM are crucial for clinical translation.