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Experiments with extracorporeal shock wave nephrolithotripsy.

A A Li1, N I Alekseyeva, Andriyanov YuV

  • 1Moscow Central Scientific Research Institute of Health Resort and Physical Therapy, USSR.

International Urology and Nephrology
|January 1, 1989
PubMed
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This study shows shock waves effectively break down kidney stones in rabbits. Struvite stones required fewer pulses than calcium oxalate stones, with no soft tissue damage observed.

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Urology

Background:

  • Renal calculi (kidney stones) are a common and painful condition.
  • Current treatments for kidney stones can be invasive.
  • Extracorporeal shock wave lithotripsy (ESWL) is a non-invasive treatment option.

Purpose of the Study:

  • To evaluate the efficacy of shock wave lithotripsy in disintegrating implanted renal calculi in a live animal model.
  • To compare the number of shock wave pulses required to break down different types of kidney stones.
  • To assess the safety of shock wave treatment on surrounding soft tissues.

Main Methods:

  • Experiments were conducted on 14 live rabbits with implanted renal calculi from nephrolithiasis patients.
  • Shock waves were applied to disintegrate the implanted stones.

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  • The number of shock wave pulses needed to fragment struvite and calcium oxalate stones was recorded.
  • Post-treatment examination assessed soft tissue damage.

    • Main Results:

    • Shock waves successfully disintegrated implanted kidney stones in rabbits.
    • Fewer pulses (100-150) were needed for struvite stones compared to calcium oxalate stones (400-800).
    • No gross damage to soft tissues was observed after multiple shock wave exposures.

    Conclusions:

    • Shock wave lithotripsy is an effective method for kidney stone disintegration.
    • Different stone compositions require varying numbers of shock wave pulses for fragmentation.
    • The treatment demonstrated a favorable safety profile regarding soft tissue integrity.