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Apoptosis01:30

Apoptosis

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Related Experiment Video

Updated: Apr 7, 2026

Phagocytosis Assay for Apoptotic Cells in Drosophila Embryos
10:06

Phagocytosis Assay for Apoptotic Cells in Drosophila Embryos

Published on: August 3, 2017

10.5K

Studying Apoptosis in Drosophila.

Donna Denton1, Sharad Kumar1

  • 1Centre for Cancer Biology, University of South Australia, Adelaide, South Australia 5001, Australia.

Cold Spring Harbor Protocols
|July 3, 2015
PubMed
Summary

This study introduces methods to monitor apoptosis, the process of programmed cell death, in Drosophila. These techniques are crucial for understanding how cell death is regulated during development and in response to DNA damage.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Genetics

Background:

  • Apoptosis, or programmed cell death, is a fundamental biological process conserved across evolution.
  • The caspase family of cysteine proteases plays a central role in regulating apoptosis.
  • Model organisms, particularly Drosophila, offer valuable insights into conserved apoptotic mechanisms.

Purpose of the Study:

  • To introduce methodologies for monitoring apoptosis in Drosophila.
  • To facilitate the study of apoptosis during Drosophila development.
  • To enable the investigation of apoptotic responses in Drosophila cell lines.

Main Methods:

  • The discussion focuses on introducing established and novel techniques for visualizing and quantifying apoptosis.
  • Methodologies cover both in vivo studies during development and in vitro analyses using cell lines.

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  • Specific techniques are detailed to allow researchers to apply them effectively.

    • Main Results:

    • The abstract does not detail specific experimental results but focuses on the presentation of methodologies.
    • The described methods are applicable to various contexts of apoptosis induction.
    • The utility of Drosophila as a model for studying apoptosis is highlighted.

    Conclusions:

    • Effective methodologies are essential for advancing our understanding of apoptosis.
    • Drosophila serves as a powerful and accessible model system for apoptosis research.
    • The introduced techniques will aid future studies on programmed cell death regulation.