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Region-specific changes in brain diffusivity in fetal isolated mild ventriculomegaly
Gal Yaniv1,2,3, Eldad Katorza4, Ronen Bercovitz5
1Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv, Israel. mdgalyaniv13@gmail.com.
European Radiology
|July 3, 2015
Summary
Isolated mild ventriculomegaly (IMVM) impacts fetal brain apparent diffusion coefficient (ADC) values differently based on symmetry. These distinct changes in ADC values may reflect underlying pathophysiological differences in various IMVM patterns.
Area of Science:
- Neuroimaging
- Fetal Medicine
- Diffusion Tensor Imaging
Background:
- Isolated mild ventriculomegaly (IMVM) is a common finding in fetal brain imaging.
- Understanding the impact of IMVM on brain development is crucial for predicting outcomes.
Purpose of the Study:
- To investigate the effect of symmetric and asymmetric isolated mild ventriculomegaly on apparent diffusion coefficient (ADC) values in specific fetal brain regions.
Main Methods:
- Compared fetal head MRI scans of 67 IMVM cases with 38 control scans.
- Classified IMVM cases into asymmetrical (AVM), symmetrical (SVM), and asymmetrical with one normal ventricle (AV1norm) groups.
- Analyzed ADC values in basal ganglia, frontal, and temporal lobes.
Main Results:
- Elevated ADC values in basal ganglia for SVM and AV1norm groups.
- High diffusivity in basal ganglia ipsilateral to the enlarged atrium in AV1norm.
- Reduced ADC values in frontal lobes for AVM and SVM groups.
- Reduced ADC values in temporal lobes for the AVM group.
Conclusions:
- Isolated mild ventriculomegaly is associated with region-specific alterations in fetal brain ADC values.
- Different patterns of IMVM correlate with distinct diffusion changes, suggesting varied pathophysiological mechanisms.
