[Vacuolar H(+)-ATPase and the Secondary Transporters: Their Identification, Mechanism, Function and Physiological
1Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Abstract:
Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are energetically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.
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