Nuclear medicine studies of aging--IX. Resting left ventricular ejection fraction-diastolic area relationship in the...

We retrospectively investigated the relationship between left ventricular ejection fraction (EF) and end diastolic cross sectional area (DCS), by means of gated cardiac blood pool studies, in 62 individuals (68 studies) who were of age 85 y or older. In these "oldest old", a plot of log ejection fraction as a function of log cross sectional area revealed good correlation (r = 0.66). The graph demonstrated the increase in heart size with a falling ejection fraction. Of the "oldest old", 38% had EF values at or above 55%. By comparison, in a group of 100 patients of ages 55-75 y, 32% had EF values of or above 55%. In the "oldest old" 13/68 (19%) had "hyperdynamic" EF values over 65%; in the 55-75 y old group, this value was 16%. The log-log plot was divided into four quadrants by two lines (one at a DCS of 26 cm2 and the other at EF of 55%). Possible prognostic significance of each of these four categories will have to be determined by following the patients and sorting out the contributions of such factors as hypertension, coronary artery disease and medications.