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Updated: Apr 7, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
HIV burden in men who have sex with men: a prospective cohort study 2007-2012
Zhongwei Jia1, Xiaojie Huang2, Hao Wu2
11] National Institute of Drug Dependence, Health Science Center, Peking University Beijing 100191, China [2] Peking University Clinical Research Institute, Health Science Center, Peking University Beijing 100191, China [3] Takemi Program in International Health, Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Abstract:
We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 enrollees who were HIV-negative at enrollment and completed at least one follow-up interview, we identified 440 incident cases of HIV in the follow up period: this constituted an HIV incidence rate of 7.1 per 100 person-years (95% CI: 6.4-7.7). Early treatment of syphilis may have significantly reduced risk of HIV infection (RR: 1.45, 95% CI: 1.11-1.93), while MSM presenting perfect compliance in the cohort did not show reduction in HIV infection. Our study suggested that HIV incidence has been remained high in this sample of Chinese MSM during the intensive preventive intervention, suggesting that we need to find new strategies to prevent HIV infection in this population.
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